With a population of over 12 million, Mumbai is one of megacities of the world and is the commercial and financial capital of India. The city is vulnerable to a multitude of natural disasters such as earthquakes, cyclones, and floods and manmade disasters such as terrorism and urban unrest. The large and diversified population, high population density and unique geographical constraints make the city extremely vulnerable to devastating consequences of disasters. The Municipal Corporation of Greater Mumbai, in cooperation with the state government, expert organizations and other stakeholders has developed a comprehensive disaster management system for the city. This paper describes the salient features of the system and gives brief details of some other initiatives taken for improving the resilience of the city to different disasters.